Ambrogi Lorenzini C, Baldi E, Bucherelli C, Tassoni G
Dipartimento di Scienze Fisiologiche, Firenze, Italy.
Pharmacol Biochem Behav. 1992 Apr;41(4):715-8. doi: 10.1016/0091-3057(92)90217-4.
The antiamnesic activity of minaprine has been studied in male Wistar rats. Two multitrial paradigms were employed: the light-dark box test (aversive stimulus: 0.6-mA foot-shocks) and the tail-handling test (aversive stimulus: manual tail-handling). In both paradigms, intraperitoneal scopolamine administration 30 min before testing significantly impaired the acquisition of the passive avoidance conditioned response. There were no significant differences in either paradigm between control rats and those to whom scopolamine and minaprine were simultaneously administered. These results show that minaprine fully protects the acquisition process of conditioned responses against scopolamine impairment not only in one-trial tests but also in multitrial paradigms. The effects of minaprine in reversing memory deficits are discussed in relation to its stimulating activity on central cholinergic systems.
已在雄性Wistar大鼠中研究了米那普明的抗遗忘活性。采用了两种多试验范式：明暗箱试验（厌恶刺激：0.6毫安足部电击）和尾处理试验（厌恶刺激：手动尾处理）。在这两种范式中，测试前30分钟腹腔注射东莨菪碱显著损害了被动回避条件反应的习得。在对照大鼠与同时给予东莨菪碱和米那普明的大鼠之间，两种范式均无显著差异。这些结果表明，米那普明不仅在单次试验测试中，而且在多试验范式中，都能充分保护条件反应的习得过程免受东莨菪碱损害。结合其对中枢胆碱能系统的刺激活性，讨论了米那普明在逆转记忆缺陷方面的作用。
