Orikasa S, Saito M, Kawashima T
Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd., Kanagawa, Japan.
Pharmacol Biochem Behav. 1992 Apr;41(4):855-7. doi: 10.1016/0091-3057(92)90239-c.
We examined the electrical resistance of the paw pads of mice under the same conditions as used previously in studies of the passive avoidance response. Administration of scopolamine (0.05-1 mg/kg, SC) 10 or 30 min prior to placement of animals in an experimental box resulted in a profound increase in electrical resistance. In contrast, subcutaneous injection of butylscopolamine (1-20 mg/kg), diazepam (1 or 2 mg/kg), or pentobarbital (10 or 20 mg/kg) did not substantially alter subject resistance. Scopolamine may act on the CNS to induce increased paw skin resistance.
我们在与先前被动回避反应研究相同的条件下，检测了小鼠爪垫的电阻。在将动物放入实验箱前10或30分钟给予东莨菪碱（0.05 - 1毫克/千克，皮下注射），会导致电阻显著增加。相比之下，皮下注射丁溴东莨菪碱（1 - 20毫克/千克）、地西泮（1或2毫克/千克）或戊巴比妥（10或20毫克/千克），并未显著改变实验对象的电阻。东莨菪碱可能作用于中枢神经系统，从而导致爪垫皮肤电阻增加。
