Liu Meng-zhong, Wang Xiu-shen, Cai Ling, Liu Hui, Chen Er-cheng, Cui Nian-ji
Cancer Hospital, Sun Yat-sen University, Guangzhou 510060, China.
Zhonghua Zhong Liu Za Zhi. 2005 Feb;27(2):122-5.
To analyze treatment and prognostic factors of 74 patients with dermatofibro-sarcoma protuberans (DFSP).
From August 1990 to November 1999, 74 patients with DFSP confirmed pathologically were treated. There were 52 males and 22 females with a median age of 37 years (range 4 to 80 years) on diagnosis. Seventeen patients were treated by extensive excision and 2 by limited excision. Fifty-two patients had surgical resection alone (S), and 22 postoperative radiotherapy (S + R) of 50-70 Gy. The multivariate parameters were analyzed using Cox model. Kaplan-Meier and Log-Rank test were used to evaluate the results of the recurrence-free survival.
The rate of recurrence was 28.4% for all patients. The 5-year recurrence-free survival rate (RFSR) was 66.6% and the 10-year RFSR was 52.5%. The 5-year and 10-year in the S group were 58.4% and 41.2%, compared with 90.0% and 83.3% in the S + R group (P < 0.05). The 5-year and 10-year RFSR in the pathologically positive margin group were 57.5% and 41.4% respectively, compared with the 75.0% and 56.6% in the pathologically negative group (P < 0.05). Multivariate analysis suggested radiotherapy and negative pathological margins were favorable prognostic factors.
Post-operation radiotherapy and pathological margin are the independent prognostic factors.
分析74例隆突性皮肤纤维肉瘤（DFSP）患者的治疗及预后因素。
1990年8月至1999年11月，对74例经病理确诊的DFSP患者进行治疗。诊断时，男性52例，女性22例，中位年龄37岁（范围4至80岁）。17例患者接受广泛切除，2例接受有限切除。52例患者仅接受手术切除（S），22例患者术后接受50 - 70 Gy的放疗（S + R）。使用Cox模型分析多变量参数。采用Kaplan - Meier法和Log - Rank检验评估无复发生存结果。
所有患者的复发率为28.4%。5年无复发生存率（RFSR）为66.6%，10年RFSR为52.5%。S组的5年和10年RFSR分别为58.4%和41.2%，而S + R组为90.0%和83.3%（P < 0.05）。病理切缘阳性组的5年和10年RFSR分别为57.5%和41.4%，病理切缘阴性组为75.0%和56.6%（P < 0.05）。多变量分析表明放疗和病理切缘阴性是有利的预后因素。
术后放疗和病理切缘是独立的预后因素。
