血浆催乳素和高香草酸作为男性精神分裂症患者维持性氟哌啶醇治疗期间精神病理学和异常运动的标志物。

Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia.

作者信息

Newcomer J W, Riney S J, Vinogradov S, Csernansky J G

机构信息

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.

出版信息

Psychiatry Res. 1992 Mar;41(3):191-202. doi: 10.1016/0165-1781(92)90001-j.

DOI:10.1016/0165-1781(92)90001-j

PMID:1594706

Abstract

Measurement of plasma prolactin (PRL) concentration and plasma homovanillic acid (HVA) concentration was performed in 24 patients with schizophrenia during maintenance haloperidol treatment. A significant inverse correlation was found between plasma PRL and ratings of both dyskinesia and thought disorder. Plasma PRL was also correlated with negative symptoms. No relationship was found between plasma HVA and any symptom grouping. Twelve patients received an apomorphine challenge; a trend toward a significant inverse relationship was found between baseline dyskinesia and apomorphine-induced decreases in plasma PRL. Plasma PRL and plasma HVA may reflect different elements of dopamine function in the central nervous system during maintenance treatment; plasma PRL may be the useful marker under these conditions.

摘要

在24例接受氟哌啶醇维持治疗的精神分裂症患者中，检测了血浆催乳素（PRL）浓度和血浆高香草酸（HVA）浓度。发现血浆PRL与运动障碍及思维障碍评分之间存在显著负相关。血浆PRL也与阴性症状相关。未发现血浆HVA与任何症状分组之间存在关联。12例患者接受了阿扑吗啡激发试验；发现基线运动障碍与阿扑吗啡诱导的血浆PRL降低之间存在显著负相关趋势。在维持治疗期间，血浆PRL和血浆HVA可能反映中枢神经系统中多巴胺功能的不同方面；在这些情况下，血浆PRL可能是有用的标志物。