Andia I, Zumarraga M, Zabalo M J, Bulbena A, Davila R
Departamento de Investigacion Neuroquimica, Servicio Vasco de Salud, Zamudio, Vizcaya, Spain.
Biol Psychiatry. 1998 Jan 1;43(1):20-3. doi: 10.1016/s0006-3223(97)00257-6.
Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment.
Twenty-six elderly women who gave informed consent were divided into two groups, with or without tardive dyskinesia, and subjected to an 80-day washout, after which both the dyskinetic and nondyskinetic group was divided, and half of each group given haloperidol or clozapine.
The nondyskinetic group had a brief rise in plasma HVA, then a decline. The dyskinetic group had no change in plasma HVA. Neither group challenged with clozapine had any change in plasma HVA.
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