氟哌啶醇与氯氮平对伴有或不伴有迟发性运动障碍的老年精神分裂症患者血浆高香草酸的不同影响。
Differential effect of haloperidol and clozapine on plasma homovanillic acid in elderly schizophrenic patients with or without tardive dyskinesia.
作者信息
Andia I, Zumarraga M, Zabalo M J, Bulbena A, Davila R
机构信息
Departamento de Investigacion Neuroquimica, Servicio Vasco de Salud, Zamudio, Vizcaya, Spain.
出版信息
Biol Psychiatry. 1998 Jan 1;43(1):20-3. doi: 10.1016/s0006-3223(97)00257-6.
BACKGROUND
Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment.
METHODS
Twenty-six elderly women who gave informed consent were divided into two groups, with or without tardive dyskinesia, and subjected to an 80-day washout, after which both the dyskinetic and nondyskinetic group was divided, and half of each group given haloperidol or clozapine.
CONCLUSIONS
The nondyskinetic group had a brief rise in plasma HVA, then a decline. The dyskinetic group had no change in plasma HVA. Neither group challenged with clozapine had any change in plasma HVA.
背景
已发现血浆高香草酸（HVA）在接受数天氟哌啶醇激发试验后的变化可预测更长治疗期内对氟哌啶醇的治疗反应。
方法
26名签署知情同意书的老年女性被分为两组，一组有迟发性运动障碍，另一组无，进行80天的洗脱期，之后将运动障碍组和非运动障碍组再各自分组，每组一半给予氟哌啶醇或氯氮平。
结论
非运动障碍组血浆HVA短暂升高，然后下降。运动障碍组血浆HVA无变化。两组接受氯氮平激发试验的患者血浆HVA均无变化。
Zotero 插件