Dryden Donna M, Saunders L Duncan, Rowe Brian H, May Laura A, Yiannakoulias Niko, Svenson Lawrence W, Schopflocher Donald P, Voaklander Donald C
British Columbia Rural and Remote Health Research Institute, University of Northern British Columbia, Prince George, BC, Canada.
Neuroepidemiology. 2005;25(2):55-61. doi: 10.1159/000086284. Epub 2005 Jun 8.
To describe the epidemiology of depression following traumatic spinal cord injury (SCI) and identify risk factors associated with depression.
This population-based cohort study followed individuals from date of SCI to 6 years after injury. Administrative data from a Canadian province with a universal publicly funded health care system and centralized databases were used. A Cox proportional hazards model was developed to identify risk factors.
Of 201 patients with SCI, 58 (28.9%) were treated for depression. Individuals at highest risk were those with a pre-injury history of depression [hazard rate ratio (HRR) 1.6; 95% CI: 1.1-2.3], a history of substance abuse (HRR 1.6; 95% CI: 1.2-2.3) or permanent neurological deficit (HRR 1.6; 95% CI: 1.2-2.1).
Depression occurs commonly and early in persons who sustain an SCI. Both patient and injury factors are associated with the development of depression. These should be used to target patients for mental health assessment and services during initial hospitalization and following discharge into the community.
描述创伤性脊髓损伤（SCI）后抑郁症的流行病学特征，并确定与抑郁症相关的危险因素。
这项基于人群的队列研究对个体从脊髓损伤之日起随访至受伤后6年。使用了来自加拿大一个拥有全民公共资助医疗保健系统和集中数据库的省份的行政数据。建立了Cox比例风险模型以确定危险因素。
在201例脊髓损伤患者中，58例（28.9%）接受了抑郁症治疗。风险最高的个体是那些受伤前有抑郁症病史的人[风险率比（HRR）1.6；95%置信区间：1.1 - 2.3]、有药物滥用史的人（HRR 1.6；95%置信区间：1.2 - 2.3）或永久性神经功能缺损的人（HRR 1.6；95%置信区间：1.2 - 2.1）。
脊髓损伤患者中抑郁症常见且出现较早。患者因素和损伤因素均与抑郁症的发生有关。这些因素应用于在初次住院期间及出院后进入社区时针对患者进行心理健康评估和提供服务。
