多药耐药基因1（MDR1）的C3435T多态性与成人胶质瘤易感性
The C3435T polymorphism of MDR1 and susceptibility to adult glioma.
作者信息
Miller Katie L, Kelsey Karl T, Wiencke John K, Moghadassi Michelle, Miike Rei, Liu Mei, Wrensch Margaret
机构信息
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Neuroepidemiology. 2005;25(2):85-90. doi: 10.1159/000086288. Epub 2005 Jun 8.
INTRODUCTION
The multidrug resistance-1 (MDR1) gene encodes a pump that prevents potentially carcinogenic substances from crossing the blood-brain barrier. We compare adult glioma cases and controls for the C3435T polymorphism that has been associated with reduced MDR1 expression.
METHODS
Adult glioma in the San Francisco Bay area and population-based controls were identified between 1991-1994 and 1997-1999. Genotyped cases (n = 458) and controls (n = 528) were compared using logistic regression controlling for age, gender and ethnicity, with later stratification by ethnicity, gender and histology.
RESULTS
With CC as the referent, the TT genotype was nonsignificantly less frequent among cases compared to controls (OR, 0.87; 95% CI: 0.6, 1.2). After stratification, only male glioblastoma was associated with TT genotype (OR, 0.51; 95% CI: 0.3, 1.0).
CONCLUSIONS
Although the C3435T polymorphism does not appear to be associated with other types of glioma, we cannot rule out that this MDR1 polymorphism may be associated with glioblastoma among men.
引言
多药耐药-1（MDR1）基因编码一种泵，可阻止潜在致癌物质穿过血脑屏障。我们比较了成人胶质瘤病例和对照中与MDR1表达降低相关的C3435T多态性。
方法
1991年至1994年以及1997年至1999年期间，在旧金山湾区确定了成人胶质瘤病例和基于人群的对照。使用逻辑回归对年龄、性别和种族进行控制，对基因分型的病例（n = 458）和对照（n = 528）进行比较，随后按种族、性别和组织学进行分层。
结果
以CC为参照，与对照相比，病例中TT基因型的频率略低，但无统计学意义（比值比，0.87；95%置信区间：0.6，1.2）。分层后，仅男性胶质母细胞瘤与TT基因型相关（比值比，0.51；95%置信区间：0.3，1.0）。
结论
虽然C3435T多态性似乎与其他类型的胶质瘤无关，但我们不能排除这种MDR1多态性可能与男性胶质母细胞瘤有关。
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