单个淋巴结内滤泡性淋巴瘤转化为伯基特样淋巴瘤。

Transformation of follicular lymphoma to Burkitt-like lymphoma within a single lymph node.

作者信息

Mukhopadhyay Sanjay, Readling Joseph, Cotter Philip D, Shrimpton Anthony E, Sidhu Jagmohan S

机构信息

Department of Pathology, State University of New York Upstate Medical University, Syracuse, 13210, USA.

出版信息

Hum Pathol. 2005 May;36(5):571-5. doi: 10.1016/j.humpath.2005.01.004.

DOI:10.1016/j.humpath.2005.01.004

PMID:15948125

Abstract

Aberrant expression of bcl-2 , caused by a t(14;18) translocation, is most commonly associated with follicular lymphoma. In a subset of these tumors, additional acquisition of a translocation involving c-myc leads to transformation to a high-grade lymphoma. We report a case of follicular lymphoma containing a t(14;18) translocation transforming into a Burkitt-like lymphoma containing the original t(14;18) as well as an additional t(8;14). The latter translocation resulted in the phenotype of Burkitt-like lymphoma, and the transformation from follicular lymphoma to Burkitt-like lymphoma was demonstrable within a single lymph node. To the best of our knowledge, this is the first report of a case documenting direct transformation of follicular lymphoma into Burkitt-like lymphoma in the same lymph node. This case illustrates the dramatic oncogenic stimulus that results from the inhibition of apoptosis by bcl-2 combined with the deregulation of cell growth by c-myc .

摘要

由t(14;18)易位导致的bcl-2异常表达最常与滤泡性淋巴瘤相关。在这些肿瘤的一个亚组中，额外获得涉及c-myc的易位会导致向高级别淋巴瘤转化。我们报告了一例滤泡性淋巴瘤病例，其含有t(14;18)易位，转化为伯基特样淋巴瘤，同时含有原始的t(14;18)以及额外的t(8;14)。后一种易位导致了伯基特样淋巴瘤的表型，并且在单个淋巴结内可证实从滤泡性淋巴瘤向伯基特样淋巴瘤的转化。据我们所知，这是首例记录同一淋巴结内滤泡性淋巴瘤直接转化为伯基特样淋巴瘤的病例报告。该病例说明了bcl-2抑制凋亡与c-myc细胞生长失调相结合所产生的显著致癌刺激。