滤泡性淋巴瘤转化为高级别B细胞淋巴瘤/白血病，伴有额外的t(2;8)(p12;q24)，c-MYC和BCL-2呈反向表达，以及轻链转换。

Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch.

作者信息

Mannouji Kiyohito, Tasaka Taizo, Akiyama Takashi, Irei Isao, Sano Fuminori, Matsuhashi Yoshiko, Wada Hideho, Tohyama Kaoru, Sugihara Takashi, Sadahira Yoshito

机构信息

Division of Hematology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan.

出版信息

Pathol Int. 2009 Apr;59(4):261-4. doi: 10.1111/j.1440-1827.2009.02361.x.

DOI:10.1111/j.1440-1827.2009.02361.x

PMID:19351371

Abstract

Transformation from follicular lymphoma (FL) to high-grade B-cell lymphoma/leukemia (BLL) has been reported in patients with additional translocations involving the c-MYC gene. The previously reported cases were related to t(8;14) and t(8;22) but not to t(2;8). Herein is reported an FL that terminated in BLL following additional t(2;8). In accordance with previous reports, increased expression of c-MYC was observed in the present case but, interestingly, BCL-2 expression was inversely decreased after the transformation. In addition, the cell-surface immunoglobulin light-chain of lymphoma cells was initially kappa type and was then gradually replaced with the lambda type after transformation. Downregulation of BCL-2 and light-chain switch have rarely been reported in previous cases of FL transformation involving c-MYC, suggesting that additional t(2;8) translocation may play a role in these events.

摘要

据报道，在伴有涉及c-MYC基因的其他易位的滤泡性淋巴瘤（FL）患者中会发生向高级别B细胞淋巴瘤/白血病（BLL）的转化。先前报道的病例与t(8;14)和t(8;22)有关，但与t(2;8)无关。本文报道了1例在发生额外的t(2;8)后最终发展为BLL的FL。与先前报道一致，在本病例中观察到c-MYC表达增加，但有趣的是，转化后BCL-2表达反而下降。此外，淋巴瘤细胞的细胞表面免疫球蛋白轻链最初为κ型，转化后逐渐被λ型取代。在先前涉及c-MYC的FL转化病例中，很少报道BCL-2下调和轻链转换，这表明额外的t(2;8)易位可能在这些事件中起作用。