Gudnadottir G S, Magnusson K P, Stefansson E, Jonasson F, Helgadottir G, Sigurdsson H
Department of Ophthalmology, University of Iceland, Landspitali, Reykjavik, Iceland.
Acta Ophthalmol Scand. 2005 Jun;83(3):333-6. doi: 10.1111/j.1600-0420.2005.00451.x.
To study time patterns in bilateral exudative age-related macular degeneration (AMD) and the pattern of drusen before and after the onset of exudative AMD.
Out of 2220 individuals in the Icelandic genetic study of AMD, 151 had bilateral exudative AMD. We searched for previous records in the Icelandic University Retina Unit. For the 65 patients with a fluorescein angiography record of both eyes, we established the time between the onset of disease in each eye. For the 53 patients with colour fundus photographs of the latter eye taken prior to the occurrence of exudative disease, we graded the drusen before and after the onset of exudative AMD in the second eye.
The time interval between the onset of exudative AMD in the first and second eyes was 2.5 years (95% CI: 1.8-3.2; n = 65) and the median was 1.8 years. In 82% of cases the second eye was affected within 4 years. Soft drusen in the macula were found in 95% of eyes that later developed exudative disease (n = 53). Soft and hard drusen decreased in number in the central macula following the development of exudative disease.
Bilateral exudative AMD develops within a few years in both eyes. Drusen are less visible following the onset of exudative AMD in the second eye.
研究双侧渗出性年龄相关性黄斑变性（AMD）的时间模式以及渗出性AMD发病前后的玻璃膜疣模式。
在冰岛AMD基因研究的2220名个体中，151人患有双侧渗出性AMD。我们在冰岛大学视网膜科查找既往记录。对于65例双眼均有荧光素血管造影记录的患者，我们确定了每只眼睛发病的时间间隔。对于53例在渗出性疾病发生前拍摄了后一只眼睛彩色眼底照片的患者，我们对第二只眼睛渗出性AMD发病前后的玻璃膜疣进行了分级。
第一只和第二只眼睛渗出性AMD发病的时间间隔为2.5年（95%CI：1.8 - 3.2；n = 65），中位数为1.8年。82%的病例中，第二只眼睛在4年内受到影响。在95%后来发展为渗出性疾病的眼睛（n = 53）中发现黄斑区有软性玻璃膜疣。渗出性疾病发生后，中央黄斑区的软性和硬性玻璃膜疣数量减少。
双眼双侧渗出性AMD在几年内发展。第二只眼睛渗出性AMD发病后，玻璃膜疣不太明显。
