Senju Atsushi, Tojo Yoshikuni, Yaguchi Kiyoshi, Hasegawa Toshikazu
Department of Cognitive and Behavioral Science, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Neuropsychologia. 2005;43(9):1297-306. doi: 10.1016/j.neuropsychologia.2004.12.002. Epub 2005 Jan 24.
This study investigated event-related potentials (ERP) during an oddball task in which detection of specific eye direction was required of children with and without autism. The detection of a change in eye direction elicited occipito-temporal negativity, which had two major differences between children with and without autism. First, while this occipito-temporal negativity predominated in the right hemisphere of typically developed children, it was distributed equally bilaterally in children with autism. Second, the amplitude of this negativity was more pronounced in typically developed children in response to the detection of direct gaze as compared to averted gaze, but was not sensitive to direct/averted gaze direction in children with autism, which converges with behavioral reports. The results concur with previous literature, suggesting the importance of the right hemisphere, especially the superior temporal sulcus, in gaze processing. Results indicate that deviant neural substrates might be involved in gaze processing in individuals with autism.
本研究调查了患有和未患自闭症的儿童在一项异常球任务中的事件相关电位（ERP），该任务要求检测特定的眼睛方向。眼睛方向变化的检测引发了枕颞负波，在患自闭症和未患自闭症的儿童之间存在两个主要差异。首先，虽然这种枕颞负波在发育正常儿童的右半球占主导，但在自闭症儿童中双侧分布均等。其次，与回避注视相比，发育正常儿童在检测到直接注视时这种负波的幅度更明显，但自闭症儿童对直接/回避注视方向不敏感，这与行为报告一致。结果与先前文献相符，表明右半球，尤其是颞上沟，在注视处理中具有重要性。结果表明，异常的神经基质可能参与自闭症个体的注视处理。
