Kitazaki Takeshi, Fukuda Masaaki, Soda Hiroshi, Kohno Shigeru
Internal Medicine, Japanese Red Cross Nagasaki Atomic Bomb Hospital, Nagasaki 852-8511, Japan.
Lung Cancer. 2005 Jul;49(1):125-8. doi: 10.1016/j.lungcan.2004.11.027.
Two Japanese females complained of cough and bronchorrhea for which chest radiographs showed infiltrate in the lungs. The patients were subsequently diagnosed as having bronchioloalveolar carcinoma by transbronchial lung biopsy. After receiving systemic chemotherapy, their symptoms were slightly improved. A few months later, their bronchorrhea and dyspnea worsened, and they were then treated with gefitinib, a selective epidermal growth factor receptor tyrosine kinase inhibitor. Bronchorrhea and dyspnea were improved within 24 h after treatment with gefitinib where the improvement was evident after 6 h for one patient and 24 h for the other patient. Thereafter, their radiological findings showed gradual improvement. Rapid relief of bronchorrhea preceded the improvement seen by the radiological findings. These observations suggest that gefitinib may inhibit mucin production as well as exert anti-proliferative activity against bronchioloalveolar carcinoma.
两名日本女性主诉咳嗽和支气管分泌增多，胸部X光片显示肺部有浸润影。随后经支气管肺活检，这两名患者被诊断为细支气管肺泡癌。接受全身化疗后，她们的症状稍有改善。几个月后，她们的支气管分泌增多和呼吸困难加重，随后接受了吉非替尼治疗，吉非替尼是一种选择性表皮生长因子受体酪氨酸激酶抑制剂。使用吉非替尼治疗后24小时内，支气管分泌增多和呼吸困难有所改善，其中一名患者在治疗6小时后改善明显，另一名患者在24小时后改善明显。此后，她们的影像学检查结果逐渐改善。支气管分泌增多的迅速缓解早于影像学检查所见的改善。这些观察结果表明，吉非替尼可能抑制粘蛋白生成，并对细支气管肺泡癌发挥抗增殖活性。
