性别决定：两个Sox基因的故事。
Sex determination: a tale of two Sox genes.
作者信息
Koopman Peter
机构信息
Division of Molecular Genetics and Developmental Biology, and ARC Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia.
出版信息
Trends Genet. 2005 Jul;21(7):367-70. doi: 10.1016/j.tig.2005.05.006.
Vertebrates use many different strategies to determine sex, but the Sox9 gene is a common thread, probably acting as the pivotal gene that controls the male-determining pathway. It now appears that Sox9 is not alone in this role, and that a closely related gene, Sox8, can partly substitute for Sox9. But is this a clever backup strategy to safeguard male development, or a relic of the past?
脊椎动物采用多种不同策略来确定性别，但Sox9基因是一个共同因素，可能作为控制雄性决定途径的关键基因发挥作用。现在看来，在这个作用中Sox9并非独自发挥作用，一个密切相关的基因Sox8可以部分替代Sox9。但这是保障雄性发育的巧妙备用策略，还是过去的遗留物呢？
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