Kolesnikov Tereza, Beckendorf Steven K
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Dev Biol. 2005 Aug 1;284(1):102-11. doi: 10.1016/j.ydbio.2005.04.037.
Directed migration is pivotal for the proper placement and function of nearly all organs. The majority of known guidance molecules involved in directed migration have been identified from studies of migrating axons during nervous system development. Here, we show that at least two of these axon guidance molecules, NETRIN and SLIT, act through their canonical receptors, to guide Drosophila embryonic salivary glands. NETRIN serves as a chemo-attractant while SLIT functions antagonistically to NETRIN as a chemo-repellent during salivary gland migration. CNS midline expression of both NETRIN and SLIT directs the glands to move unswervingly parallel to the CNS. NETRIN expression is also required in the visceral mesoderm, along which the glands move during their migration. We propose that analogous to axon guidance, a balance between chemo-attractants and chemo-repellents is required for the proper migratory path of the developing salivary glands.
定向迁移对于几乎所有器官的正确定位和功能至关重要。参与定向迁移的大多数已知导向分子是在神经系统发育过程中对迁移轴突的研究中发现的。在此，我们表明，这些轴突导向分子中的至少两种，即网蛋白（NETRIN）和slit蛋白，通过其经典受体发挥作用，引导果蝇胚胎唾液腺迁移。在唾液腺迁移过程中，网蛋白作为化学引诱剂，而slit蛋白则作为化学排斥剂与网蛋白起拮抗作用。网蛋白和slit蛋白在中枢神经系统中线的表达引导唾液腺沿着中枢神经系统平行稳定地移动。在内脏中胚层中也需要网蛋白的表达，唾液腺在迁移过程中沿着该中胚层移动。我们提出，类似于轴突导向，发育中的唾液腺的正确迁移路径需要化学引诱剂和化学排斥剂之间的平衡。
