氨基哌啶苯甲酰胺作为MCHr1拮抗剂的鉴定。
Identification of aminopiperidine benzamides as MCHr1 antagonists.
作者信息
Vasudevan Anil, Verzal Mary K, Wodka Derek, Souers Andrew J, Blackburn Christopher, Che Jennifer Lee, Lai Sujen, Brodjian Sevan, Falls Doug H, Dayton Brian D, Govek Elizabeth, Daniels Tom, Geddes Brad, Marsh Kennan C, Hernandez Lisa E, Collins Christine A, Kym Philip R
机构信息
Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.
出版信息
Bioorg Med Chem Lett. 2005 Jul 15;15(14):3412-6. doi: 10.1016/j.bmcl.2005.05.023.
PMID:15950463
Abstract
The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model.
摘要
本文描述了一系列新型含苯甲酰胺的MCHr1拮抗剂的鉴定。化合物22在饮食诱导的肥胖小鼠模型中显示出中等疗效。
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