Wang Yueping Alex, Sullivan Elizabeth A, Black Deborah, Dean Jishan, Bryant Joanne, Chapman Michael
School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
Fertil Steril. 2005 Jun;83(6):1650-8. doi: 10.1016/j.fertnstert.2004.12.033.
To describe patterns of preterm birth and low birth weight (LBW) for infants born after assisted reproductive technology (ART) and determine whether these were associated with maternal or treatment characteristics.
Retrospective cohort study of national population data of infants conceived through ART.
Australian birth records from 1996 to 2000.
PATIENT(S): Eighteen thousand, four hundred twenty-nine liveborn and stillborn infants conceived through ART.
INTERVENTION(S): In vitro fertilization, intracytoplasmic sperm injection, and gamete intrafallopian transfer.
MAIN OUTCOME MEASURE(S): Preterm birth and LBW.
RESULT(S): Preterm birth and LBW were more common among singletons and twins conceived with IVF and born to nulliparous mothers. Preterm birth and LBW were, respectively, 1.3 times and 1.5 times more likely to occur among singletons conceived by transfer of fresh embryos, compared with transfer of frozen embryos. Preterm birth and LBW was more common among couples who had female-factor infertility compared with male-factor infertility.
CONCLUSION(S): The transfer of fresh embryos and female-factor infertility were independently associated with preterm birth and LBW for both singletons and twins after ART.
描述辅助生殖技术（ART）后出生婴儿的早产和低出生体重（LBW）模式，并确定这些是否与母亲或治疗特征相关。
对通过ART受孕婴儿的全国人口数据进行回顾性队列研究。
1996年至2000年澳大利亚的出生记录。
18429例通过ART受孕的活产和死产婴儿。
体外受精、卵胞浆内单精子注射和配子输卵管内移植。
早产和低出生体重。
在通过体外受精受孕、初产妇所生的单胎和双胎中，早产和低出生体重更为常见。与冷冻胚胎移植相比，新鲜胚胎移植受孕的单胎发生早产和低出生体重的可能性分别高出1.3倍和1.5倍。与男性因素不育的夫妇相比，女性因素不育的夫妇中早产和低出生体重更为常见。
对于ART后的单胎和双胎，新鲜胚胎移植和女性因素不育与早产和低出生体重独立相关。
