Prakash Alka, Laird Susan, Tuckerman Elizabeth, Li Tin C, Ledger William L
Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Jessop Wing, Sheffield, United Kingdom.
Fertil Steril. 2005 Jun;83(6):1758-63. doi: 10.1016/j.fertnstert.2004.11.072.
To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage.
Observational clinical study.
Recurrent miscarriage clinic of a tertiary care teaching hospital.
PATIENT(S): Patients with history of recurrent miscarriage.
INTERVENTION(S): Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy.
MAIN OUTCOME MEASURE(S): Serum concentrations of inhibin A and activin A levels.
RESULT(S): Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively.
CONCLUSION(S): It is possible that inhibin A and activin A may be used as markers to predict pregnancies that are likely to miscarry.
探讨抑制素和激活素在预测复发性流产患者妊娠结局中的作用。
观察性临床研究。
一家三级护理教学医院的复发性流产诊所。
有复发性流产病史的患者。
在妊娠第5至8周期间连续测量血清抑制素A和激活素A浓度。
血清抑制素A和激活素A水平。
流产女性和活产女性在妊娠5至6周时的平均抑制素A浓度分别为33 pg/mL和51 pg/mL；两组在相同孕周时的激活素A浓度分别为534 pg/mL和643 pg/mL。2周后，流产女性和活产女性的平均抑制素A浓度分别为66 pg/mL和145 pg/mL，激活素A浓度分别为747 pg/mL和1123 pg/mL。
抑制素A和激活素A有可能作为预测可能流产妊娠的标志物。
