生长激素分泌和胰岛素样生长因子-1与非肥胖型多囊卵巢综合征患者的高雄激素血症相关。
Growth hormone secretion and insulin-like growth factor-1 are related to hyperandrogenism in nonobese patients with polycystic ovary syndrome.
作者信息
Premoli Ana Cristina, Santana Laura Ferreira, Ferriani Rui Alberto, Moura Marcos Dias de, De Sá Marcos Felipe Silva, Reis Rosana Maria dos
机构信息
Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
出版信息
Fertil Steril. 2005 Jun;83(6):1852-5. doi: 10.1016/j.fertnstert.2004.10.057.
Women of normal weight with polycystic ovary syndrome (PCOS) and hyperinsulinemia presented high growth hormone (GH) levels in response to the l-dopa test, suggesting that the action of GH and insulin-like growth factor-1 (IGF-1) might be responsible for the elevation in LH and the consequent hyperandrogenic anovulation observed in normal weight women with PCOS. Insulin resistance and obesity are related to a reduction in GH secretion in obese women with PCOS.
体重正常的多囊卵巢综合征（PCOS）和高胰岛素血症女性在左旋多巴试验中呈现高生长激素（GH）水平，这表明GH和胰岛素样生长因子-1（IGF-1）的作用可能是体重正常的PCOS女性促黄体生成素（LH）升高以及随之出现的高雄激素性无排卵的原因。胰岛素抵抗和肥胖与肥胖的PCOS女性GH分泌减少有关。
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