从长期“暴食”式可卡因给药中立即戒断会增加大鼠额叶皮质中μ-阿片受体mRNA水平。
Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex.
作者信息
Bailey Alexis, Yuferov Vadim, Bendor Jacob, Schlussman Stefan D, Zhou Yan, Ho Ann, Kreek Mary Jeanne
机构信息
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA.
出版信息
Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):258-62. doi: 10.1016/j.molbrainres.2005.02.017.
An increase in preprodynorphin (ppdyn) mRNA was detected in the caudate putamen of chronically cocaine-treated and 3-h withdrawn rats. An increase in mu-opioid receptor (MOP) mRNA levels was observed in the frontal cortex of 3-h withdrawn rats. Naloxone had no effect on the increase of MOP or ppdyn mRNA levels. The results indicate that the opioid system is altered during early withdrawal from chronic cocaine administration.
在长期接受可卡因治疗并戒断3小时的大鼠的尾状壳核中，检测到前强啡肽原（ppdyn）信使核糖核酸（mRNA）增加。在戒断3小时的大鼠的额叶皮质中，观察到μ-阿片受体（MOP）mRNA水平升高。纳洛酮对MOP或ppdyn mRNA水平的升高没有影响。结果表明，在从长期可卡因给药中早期戒断期间，阿片系统发生了改变。
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