Sellner Johann, Lenhard Thorsten, Haas Jürgen, Einsiedel Regina von, Meyding-Lamadé Uta
Department of Neurology, Ruprecht-Karls-University Heidelberg, D-69120 Heidelberg, Germany.
Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):267-71. doi: 10.1016/j.molbrainres.2005.03.011. Epub 2005 Apr 22.
Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA levels were studied in the course of murine herpes simplex virus encephalitis. Induction of GNDF and NT-3 (both P < 0.05) was found during acute encephalitis. Despite absence of clinical impairment, both neurotrophic factors were overexpressed 2 months (NT-3) and 6 months (GDNF) following infection (both P < 0.05). Neurotrophic factors play an important role in neuronal survival and recovery after acute injury to the central nervous system (CNS) and may represent an additional therapeutic target for treatment of viral encephalitis.
在小鼠单纯疱疹病毒性脑炎病程中，研究了胶质细胞源性神经营养因子（GDNF）、脑源性神经营养因子（BDNF）和神经营养因子-3（NT-3）的mRNA水平。在急性脑炎期间发现GDNF和NT-3均有诱导（两者P<0.05）。尽管没有临床损伤，但在感染后2个月（NT-3）和6个月（GDNF）时，这两种神经营养因子均过度表达（两者P<0.05）。神经营养因子在中枢神经系统（CNS）急性损伤后的神经元存活和恢复中起重要作用，可能代表病毒性脑炎治疗的另一个治疗靶点。
