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帕金森震颤及其治疗方法的建模

Modeling the Parkinson's tremor and its treatments.

作者信息

Haeri Mohammad, Sarbaz Yashar, Gharibzadeh Shahriar

机构信息

Advanced Control Systems Lab, Electrical Engineering Department, Sharif University of Technology, Azadi Ave. PO. Box 11365-9363, Tehran, Iran.

出版信息

J Theor Biol. 2005 Oct 7;236(3):311-22. doi: 10.1016/j.jtbi.2005.03.014.

Abstract

In this paper, we discuss modeling issues of the Parkinson's tremor. Through the work we have employed physiological structure as well as functioning of the parts in brain that are involved in the disease. To obtain more practical similarity, random behaviors of the connection paths are also considered. Medication or treatment of the disease both by drug prescription and electrical signal stimulation are modeled based on the same model introduced for the disease itself. Two new medication strategies are proposed based on the model to reduce the side effects caused by the present drug prescription.

摘要

在本文中,我们讨论帕金森震颤的建模问题。通过我们的工作,我们利用了与该疾病相关的大脑部位的生理结构和功能。为了获得更实际的相似性,还考虑了连接路径的随机行为。基于为该疾病本身引入的相同模型,对通过药物处方和电信号刺激进行的疾病药物治疗或治疗进行了建模。基于该模型提出了两种新的药物治疗策略,以减少当前药物处方引起的副作用。

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