丘脑中央中核/束旁核的深部脑刺激会成为晚期帕金森病震颤的新的选择性靶点吗？
Deep brain stimulation of CM/PF of thalamus could be the new elective target for tremor in advanced Parkinson's Disease?
作者信息
Peppe A, Gasbarra A, Stefani A, Chiavalon C, Pierantozzi M, Fermi E, Stanzione P, Caltagirone C, Mazzone P
机构信息
IRCCS Fondazione Santa Lucia, Roma, Italy.
出版信息
Parkinsonism Relat Disord. 2008 Aug;14(6):501-4. doi: 10.1016/j.parkreldis.2007.11.005. Epub 2008 Mar 11.
Aim of this study was to investigate whether Deep Brain Stimulation (DBS) of the Centre Median Nucleus/Parafascicular (CM/PF) Complex is useful in reducing extrapyramidal symptoms in advanced Parkinson's Disease (PD) patients. In particular, we compared the action of CM/PF and subthalamic nucleus (STN) DBS on resting hand tremor using EMG surface of ulnar and radial right-hand muscles. Our results show that C/M DBS is very effective in reducing tremor, indicating this complex as a new target in advanced PD patients.
本研究的目的是调查对中央中核/束旁核（CM/PF）复合体进行深部脑刺激（DBS）是否有助于减轻晚期帕金森病（PD）患者的锥体外系症状。特别是，我们使用右手尺侧和桡侧肌肉的肌电图表面，比较了CM/PF和丘脑底核（STN）DBS对静息性手部震颤的作用。我们的结果表明，CM DBS在减轻震颤方面非常有效，表明该复合体是晚期PD患者的一个新靶点。
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