Peppe A, Gasbarra A, Stefani A, Chiavalon C, Pierantozzi M, Fermi E, Stanzione P, Caltagirone C, Mazzone P
IRCCS Fondazione Santa Lucia, Roma, Italy.
Parkinsonism Relat Disord. 2008 Aug;14(6):501-4. doi: 10.1016/j.parkreldis.2007.11.005. Epub 2008 Mar 11.
Aim of this study was to investigate whether Deep Brain Stimulation (DBS) of the Centre Median Nucleus/Parafascicular (CM/PF) Complex is useful in reducing extrapyramidal symptoms in advanced Parkinson's Disease (PD) patients. In particular, we compared the action of CM/PF and subthalamic nucleus (STN) DBS on resting hand tremor using EMG surface of ulnar and radial right-hand muscles. Our results show that C/M DBS is very effective in reducing tremor, indicating this complex as a new target in advanced PD patients.
本研究的目的是调查对中央中核/束旁核（CM/PF）复合体进行深部脑刺激（DBS）是否有助于减轻晚期帕金森病（PD）患者的锥体外系症状。特别是，我们使用右手尺侧和桡侧肌肉的肌电图表面，比较了CM/PF和丘脑底核（STN）DBS对静息性手部震颤的作用。我们的结果表明，CM DBS在减轻震颤方面非常有效，表明该复合体是晚期PD患者的一个新靶点。
