水合氯醛。一种用于儿童镇静的有效药物，其反应取决于年龄和体重。

Chloral hydrate. An effective agent for sedation in children with age and weight dependent response.

作者信息

Hijazi Omar M, Haidar Nasser A, Al-Eissa Youssef A

机构信息

Department of Pediatrics, King Fahad National Guard Hospital, PO Box 22490, Riyadh 11426, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2005 May;26(5):746-9.

PMID:15951862

Abstract

OBJECTIVE

Diagnostic and therapeutic procedures in children are made easier using sedation. However, there is no consensus about which drug should be used to achieve this. Furthermore, none of the drugs used for sedation are risk free. The aim of this work is to study sedation indications, effectiveness, and safety at our center.

METHODS

A prospective observational study conducted at the Pediatric Day Care Unit, King Fahad National Guard Hospital, Riyadh, Saudi Arabia. The study covered 17.5 weeks in 2 periods: May 9th 1999 to June 13th 1999 and October 31st 2001 to February 11th 2002. Children <12 years were included. Collected data included demographics, indication, drug dosing and outcome. Data were reported as mean +/- SD.

RESULTS

We included 148 patients, age 38 +/- 30 months. Adequate sedation was achieved in 79% after initial chloral hydrate (CH) dose of 56.9 +/- 9.3 mg/kg, in 95% after adding 18.5 +/- 6.4 mg/kg CH and in 96% after adding second drug. Compared to nonrespondents, first CH dose respondents were younger and lower in weight. The CH side effects were few and mild.

CONCLUSION

Chloral hydrate is a safe and effective agent for sedation in children with an age and weight dependent response.

摘要

目的

使用镇静剂可使儿童的诊断和治疗程序更简便。然而，对于应使用哪种药物来实现这一点尚无共识。此外，用于镇静的药物均非无风险。这项工作的目的是研究我们中心的镇静适应症、有效性和安全性。

方法

在沙特阿拉伯利雅得法赫德国民警卫队医院儿科日间护理病房进行了一项前瞻性观察研究。该研究在两个时间段内进行，为期17.5周：1999年5月9日至1999年6月13日以及2001年10月31日至2002年2月11日。纳入年龄小于12岁的儿童。收集的数据包括人口统计学信息、适应症、药物剂量和结果。数据以平均值±标准差报告。

结果

我们纳入了148例患者，年龄为38±30个月。初始水合氯醛（CH）剂量为56.9±9.3mg/kg后，79%的患者实现了充分镇静；添加18.5±6.4mg/kg CH后，95%的患者实现了充分镇静；添加第二种药物后，96%的患者实现了充分镇静。与无反应者相比，首次使用CH剂量有反应者年龄更小且体重更低。CH的副作用较少且轻微。