Wilson Michelle E, Karaoui Mohammed, Al Djasim Leyla, Edward Deepak P, Al Shamrani Mohammad, Friedman David S
J Pediatr Ophthalmol Strabismus. 2014 May-Jun;51(3):154-9. doi: 10.3928/01913913-20140311-01. Epub 2014 Mar 18.
To determine the safety and efficacy of high-dose oral chloral hydrate for pediatric ophthalmic procedures.
This study is a retrospective review of a quality audit of pediatric sedation for ophthalmic evaluation and imaging performed at King Khaled Eye Specialist Hospital between January 1 and December 31, 2011, in children aged 1 month to 6 years.
Three hundred fifty-eight of 380 (94.2%) sedation procedures were successful after a single dose of chloral hydrate, with 356 of 380 (93.7%) children sedated within 45 minutes of the first dose. The total success rate of the sedation procedure increased to 97.9% (372 of 380) when a second dose was administered. Children adequately sedated after a single dose of chloral hydrate were on average younger and weighed less than children who required additional doses. No major adverse events were documented.
The use of chloral hydrate sedation for ophthalmic evaluation and imaging was safe and effective in this patient population with a high rate of procedure completion.
确定大剂量口服水合氯醛用于小儿眼科手术的安全性和有效性。
本研究是对2011年1月1日至12月31日在沙特国王哈立德眼科专科医院进行的小儿眼科评估和成像镇静质量审核的回顾性研究，研究对象为1个月至6岁的儿童。
380例镇静手术中有358例（94.2%）在单次给予水合氯醛后成功，380例儿童中有356例（93.7%）在首剂给药后45分钟内达到镇静效果。当给予第二剂时，镇静手术的总成功率提高到97.9%（372/380）。单次给予水合氯醛后达到充分镇静的儿童平均年龄更小，体重也低于需要额外剂量的儿童。未记录到重大不良事件。
在该患者群体中，使用水合氯醛镇静进行眼科评估和成像安全有效，手术完成率高。
