Liu Jian-ping, Ma Xu, Zhu Jia-bi
Pharmaceutical Institute, China Pharmaceutical University, Nanjing 210009, China.
Yao Xue Xue Bao. 2005 Mar;40(3):279-84.
To evaluate the correlation between the swelling equilibrium quantity (Seq), dissolution rate and amino group content which were used to estimate the degree of gelatin crosslinking, and the factors which influence the crosslinking, and to investigate the crosslinking mechanism of delayed dissolution of soft capsules.
The swelling equilibrium quantity, dissolution rate and amino group content of formaldehyde-crosslinked capsule shells were determined. Gelatin structure was analyzed by means of DSC.
A good lineal relativity was found between the swelling equilibrium quantity, dissolution rate and amino group content (r = 0.9953-0.9985). The Seq of capsule shells was influenced by high temperature, lighting and some additives. Glycine and sodium pyrosulfite might retard the decrease of Seq of capsule shells.
The swelling equilibrium quantity, dissolution rate and amino group content exhibited the same rule in gelatin crosslinking extent. High temperature, lighting and some additives might induce gelatin crosslinking. Antioxidant such as glycine and sodium pyrosulfite might retard the crosslinking.
评估用于估计明胶交联程度的溶胀平衡量（Seq）、溶解速率和氨基含量之间的相关性，以及影响交联的因素，并研究软胶囊延迟溶解的交联机制。
测定甲醛交联胶囊壳的溶胀平衡量、溶解速率和氨基含量。通过差示扫描量热法（DSC）分析明胶结构。
溶胀平衡量、溶解速率和氨基含量之间存在良好的线性相关性（r = 0.9953 - 0.9985）。胶囊壳的Seq受高温、光照和一些添加剂的影响。甘氨酸和焦亚硫酸钠可能会延缓胶囊壳Seq的降低。
溶胀平衡量、溶解速率和氨基含量在明胶交联程度上表现出相同规律。高温、光照和一些添加剂可能会诱导明胶交联。甘氨酸和焦亚硫酸钠等抗氧化剂可能会延缓交联。
Zotero 插件