Vandelli M A, Forni F, Iannuccelli V, Cameroni R
Department of Pharmaceutical Sciences, University of Modena, Italy.
J Pharm Belg. 1991 Nov-Dec;46(6):381-8.
The effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.
评估了交联剂（明胶硬化剂）浓度对明胶微球的影响。明胶硬化剂（甲醛）浓度的增加导致载药量、溶胀度和药物释放速率降低。交联剂浓度还影响吸水和药物释放动力学。本文表明，随着交联剂浓度的增加，药物释放的扩散型机制的重要性降低。
