Wang Qiang, Cao Zhao-jin, Bai Xue-tao
National Institute of Environmental Health and Related Product Safety, China CDC, Beijing 100021, China.
Wei Sheng Yan Jiu. 2005 Mar;34(2):155-8.
To study the effect of 900MHz low intensity microwave electromagnetic fields (EMF) on AMPA GluR2 and the concentration of intracellular calcium in postnatal rat cerebral cortical neurons.
Neurons were exposed to low intensity 900MHz continuous microwaves EMF (SAR = 3.22W/kg, 2.23W/kg, 1.15W/kg) for 2 hours per day in 4 or 6 consecutive days and for 12 hours at a time (SAR = 3.22W/kg). Such exposures were carried out to have knowledge of the effect of microwave on protein of GluR2 and intracellular calcium ions.
The results of immunochemistry and laser confocal scan showed that compared with sham, protein of GluR2 of exposed neurons were significantly down-regulated (P < 0.01), while intracellular calcium ions were significantly up-regulated (P < 0.01).
The microwaves play a role of accumulation in the effect on exposed neurons, the trends in dose response relationship were found between the exposure intensity and the effects, effect of the microwave on exposed neurons should be classified as athermal effects of EMF.
研究900MHz低强度微波电磁场（EMF）对新生大鼠大脑皮质神经元α-氨基-3-羟基-5-甲基-4-异恶唑丙酸型谷氨酸受体2（AMPA GluR2）及细胞内钙离子浓度的影响。
将神经元暴露于低强度900MHz连续微波电磁场（比吸收率分别为3.22W/kg、2.23W/kg、1.15W/kg），每天暴露2小时，连续暴露4或6天，每次暴露12小时（比吸收率为3.22W/kg）。进行此类暴露以了解微波对GluR2蛋白和细胞内钙离子的影响。
免疫化学和激光共聚焦扫描结果显示，与假暴露组相比，暴露神经元的GluR2蛋白显著下调（P<0.01），而细胞内钙离子显著上调（P<0.01）。
微波对暴露神经元的影响具有累积作用，暴露强度与效应之间存在剂量反应关系趋势，微波对暴露神经元的效应应归类为电磁场的非热效应。
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