翼状胬肉、睑裂斑与白内障的5年发病率

Pterygium, pinguecula, and 5-year incidence of cataract.

作者信息

Pham Thuan Quoc, Wang Jie Jin, Rochtchina Elena, Mitchell Paul

机构信息

Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Hospital, Hawkesbury Road, Westmead, NSW 2145, Australia.

出版信息

Am J Ophthalmol. 2005 Jun;139(6):1126-8. doi: 10.1016/j.ajo.2004.12.004.

DOI:10.1016/j.ajo.2004.12.004

PMID:15953456

Abstract

PURPOSE

To assess longitudinal associations between pterygium, pinguecula, and 5-year incident cataract.

DESIGN

Population-based cohort study.

METHODS

The Blue Mountains Eye Study examined 3,654 residents aged > or =49 years during 1992 to 1994 and reexamined 2,335 (75.1% of survivors) 5 years later. Slit-lamp examination recorded pterygium and pinguecula. Cataract was assessed using masked grading of lens photographs. Incidence was assessed in participants without cataract at baseline. Eye-specific data were analyzed using generalized estimating equation models, adjusting for age, sex, smoking, diabetes, and corticosteroid use.

RESULTS

Pinguecula was associated with a borderline-significant, increased risk of developing cortical cataract (adjusted odds ratio, 1.3; 95% confidence interval, 1.0 to 1.7). We found no significant association between baseline pterygium and the incidence of cortical, nuclear, or posterior subcapsular cataract.

CONCLUSIONS

Longitudinal data from the same study population provide weak support for cross-sectional associations between pinguecula and cortical cataract previously reported from our study.

摘要

目的

评估翼状胬肉、睑裂斑与5年新发白内障之间的纵向关联。

设计

基于人群的队列研究。

方法

蓝山眼研究在1992年至1994年期间对3654名年龄≥49岁的居民进行了检查，并在5年后对2335名（75.1%的幸存者）进行了复查。裂隙灯检查记录翼状胬肉和睑裂斑。使用晶状体照片的盲法分级评估白内障。在基线时无白内障的参与者中评估发病率。使用广义估计方程模型分析眼部特异性数据，并对年龄、性别、吸烟、糖尿病和皮质类固醇使用情况进行校正。