Department of Ophthalmology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Division of Vision Research for Environmental Health, Project Research Center, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
PLoS One. 2021 Jun 15;16(6):e0253093. doi: 10.1371/journal.pone.0253093. eCollection 2021.
PURPOSE: Pterygium is an ocular surface disorder mainly caused by ultraviolet (UV) light exposure. This study explored the relationships between six cataract types with pterygium and UV exposure. METHODS: We have previously studied cataracts in residents of three regions in China and Taiwan with different UV intensities. From that study, we identified 1,547 subjects with information on the presence or absence of pterygium. Pterygium severity was graded by corneal progress rate. Cataracts were graded by classification systems as three main types (cortical, nuclear, posterior subcapsular) and three subtypes (retrodots, waterclefts, fiber folds) with high prevalence in middle-aged and elderly people. We calculated the cumulative ocular UV exposure (COUV) based on subject data and National Aeronautics and Space Administration data on UV intensities and used logistic regression to calculate odds ratios for the associations of COUV, cataract, and pterygium. RESULTS: We found an overall pterygium prevalence of 23.3%, with significant variation among the three regions. Four cataract types (cortical, nuclear, posterior subcapsular, and retrodots) were significantly associated with the presence of pterygium. CONCLUSIONS: There was a significant association between COUV and pterygium, indicating that COUV is associated with the risk of pterygium development and that pterygium is useful as an index of UV exposure. Furthermore, the type of cataract in eyes with pterygium may indicate the level of UV exposure.
目的:翼状胬肉是一种主要由紫外线(UV)暴露引起的眼表疾病。本研究探讨了六种白内障类型与翼状胬肉和 UV 暴露之间的关系。
方法:我们之前曾研究过中国和台湾三个地区居民的白内障,这些地区的 UV 强度不同。从该研究中,我们确定了 1547 名存在或不存在翼状胬肉的受试者。翼状胬肉的严重程度通过角膜进展率分级。白内障根据分类系统分为三种主要类型(皮质性、核性、后囊下性)和三种亚类(后皮质点状、水隙、纤维皱襞),这些类型在中老年人中发病率较高。我们根据受试者数据和美国国家航空航天局(NASA)的 UV 强度数据计算了累积眼部 UV 暴露(COUV),并使用逻辑回归计算了 COUV、白内障和翼状胬肉之间关联的优势比。
结果:我们发现总体翼状胬肉患病率为 23.3%,三个地区之间存在显著差异。四种白内障类型(皮质性、核性、后囊下性和后皮质点状)与翼状胬肉的存在显著相关。
结论:COUV 与翼状胬肉之间存在显著关联,表明 COUV 与翼状胬肉发展的风险相关,并且翼状胬肉可用作 UV 暴露的指标。此外,翼状胬肉眼中的白内障类型可能表明 UV 暴露水平。
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