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翼状胬肉、白内障与累积眼紫外线暴露的关联性:中国汉族人群和台湾地区的横断面研究。

Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan.

机构信息

Department of Ophthalmology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.

Division of Vision Research for Environmental Health, Project Research Center, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan.

出版信息

PLoS One. 2021 Jun 15;16(6):e0253093. doi: 10.1371/journal.pone.0253093. eCollection 2021.


DOI:10.1371/journal.pone.0253093
PMID:34129614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8205177/
Abstract

PURPOSE: Pterygium is an ocular surface disorder mainly caused by ultraviolet (UV) light exposure. This study explored the relationships between six cataract types with pterygium and UV exposure. METHODS: We have previously studied cataracts in residents of three regions in China and Taiwan with different UV intensities. From that study, we identified 1,547 subjects with information on the presence or absence of pterygium. Pterygium severity was graded by corneal progress rate. Cataracts were graded by classification systems as three main types (cortical, nuclear, posterior subcapsular) and three subtypes (retrodots, waterclefts, fiber folds) with high prevalence in middle-aged and elderly people. We calculated the cumulative ocular UV exposure (COUV) based on subject data and National Aeronautics and Space Administration data on UV intensities and used logistic regression to calculate odds ratios for the associations of COUV, cataract, and pterygium. RESULTS: We found an overall pterygium prevalence of 23.3%, with significant variation among the three regions. Four cataract types (cortical, nuclear, posterior subcapsular, and retrodots) were significantly associated with the presence of pterygium. CONCLUSIONS: There was a significant association between COUV and pterygium, indicating that COUV is associated with the risk of pterygium development and that pterygium is useful as an index of UV exposure. Furthermore, the type of cataract in eyes with pterygium may indicate the level of UV exposure.

摘要

目的:翼状胬肉是一种主要由紫外线(UV)暴露引起的眼表疾病。本研究探讨了六种白内障类型与翼状胬肉和 UV 暴露之间的关系。

方法:我们之前曾研究过中国和台湾三个地区居民的白内障,这些地区的 UV 强度不同。从该研究中,我们确定了 1547 名存在或不存在翼状胬肉的受试者。翼状胬肉的严重程度通过角膜进展率分级。白内障根据分类系统分为三种主要类型(皮质性、核性、后囊下性)和三种亚类(后皮质点状、水隙、纤维皱襞),这些类型在中老年人中发病率较高。我们根据受试者数据和美国国家航空航天局(NASA)的 UV 强度数据计算了累积眼部 UV 暴露(COUV),并使用逻辑回归计算了 COUV、白内障和翼状胬肉之间关联的优势比。

结果:我们发现总体翼状胬肉患病率为 23.3%,三个地区之间存在显著差异。四种白内障类型(皮质性、核性、后囊下性和后皮质点状)与翼状胬肉的存在显著相关。

结论:COUV 与翼状胬肉之间存在显著关联,表明 COUV 与翼状胬肉发展的风险相关,并且翼状胬肉可用作 UV 暴露的指标。此外,翼状胬肉眼中的白内障类型可能表明 UV 暴露水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4790/8205177/c38d1015d7d0/pone.0253093.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4790/8205177/2c31467e6031/pone.0253093.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4790/8205177/3ed282ac1e99/pone.0253093.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4790/8205177/c38d1015d7d0/pone.0253093.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4790/8205177/2c31467e6031/pone.0253093.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4790/8205177/3ed282ac1e99/pone.0253093.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4790/8205177/c38d1015d7d0/pone.0253093.g003.jpg

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[1]
Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan.

PLoS One. 2021

[2]
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引用本文的文献

[1]
The nonlinear impact of air pollutants and solar radiation exposure on the risk of hospitalisation for pterygium among adults in Shanghai, China: a time series analysis.

J Glob Health. 2025-4-11

[2]
Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon?

Antioxidants (Basel). 2024-10-16

[3]
UV light and the ocular lens: a review of exposure models and resulting biomolecular changes.

Front Ophthalmol (Lausanne). 2024-9-5

[4]
Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation.

Sci Adv. 2024-4-26

[5]
Ultraviolet light exposure and its penetrance through the eye in a porcine model.

Int J Ophthalmol. 2023-2-18

[6]
Vision With Retrodots and Factors for Declining Visual Function.

Invest Ophthalmol Vis Sci. 2022-11-1

[7]
UV Protection in the Cornea: Failure and Rescue.

Biology (Basel). 2022-2-10

[8]
Refractive Outcomes of Simultaneous Pterygium and Cataract Surgery With Fibrin Glue.

Cureus. 2021-11-24

本文引用的文献

[1]
Degradation of connexin 50 protein causes waterclefts in human lens.

Open Med (Wars). 2020-11-17

[2]
Identification of Functional Genes in Pterygium Based on Bioinformatics Analysis.

Biomed Res Int. 2020

[3]
Activation of LncRNA FOXD2-AS1 by H3K27 acetylation regulates VEGF-A expression by sponging miR-205-5p in recurrent pterygium.

J Cell Mol Med. 2020-12

[4]
MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium.

J Transl Med. 2020-9-1

[5]
Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells.

Exp Eye Res. 2020-10

[6]
Bcl-2, p53, and Ki-67 expression in pterygium and normal conjunctiva and their relationship with pterygium recurrence.

Eur J Ophthalmol. 2020-11

[7]
Exploring the Molecular Mechanisms of Pterygium by Constructing lncRNA-miRNA-mRNA Regulatory Network.

Invest Ophthalmol Vis Sci. 2020-7-1

[8]
Clinical Aspects of Pterygium in the Presence of Cataract.

Curr Health Sci J. 2019

[9]
Prevalence and associated factors for pterygium in Han and Mongolian adults: a cross-sectional study in inner Mongolian, China.

BMC Ophthalmol. 2020-2-3

[10]
Mechanisms and biomarker candidates in pterygium development.

Arq Bras Oftalmol. 2019-9-30

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