经聚合酶链反应检测确诊的慢性复发性水痘-带状疱疹病毒角膜炎
Chronic recurrent varicella-zoster virus keratitis confirmed by polymerase chain reaction testing.
作者信息
Magone M Teresa, Nasser Robert E, Cevallos A Vicky, Margolis Todd P
机构信息
Francis I. Proctor Foundation, University of California-San Francisco, San Francisco, CA 94143-0944, USA.
出版信息
Am J Ophthalmol. 2005 Jun;139(6):1135-6. doi: 10.1016/j.ajo.2004.12.014.
PURPOSE
To report a case of chronic recurrent varicella virus epithelial keratitis in a child.
DESIGN
Case report.
METHODS
Clinical examination and polymerase chain reaction analysis of corneal epithelium.
RESULTS
A 10-year-old healthy child developed chronic recurrent varicella virus keratitis with pseudodendrites after recovering from systemic varicella. Analysis of the debrided pseudodendrites was repeatedly positive for VZV DNA and negative for HSV DNA. Treatment with oral acyclovir and topical corticosteroid drops was effective in eliminating the pseudodendrites; however, recurrences occurred once the medications were discontinued.
CONCLUSIONS
Varicella virus epithelial keratitis in children can be a recurrent chronic condition requiring prolonged treatment.
目的
报告一例儿童慢性复发性水痘病毒上皮性角膜炎病例。
设计
病例报告。
方法
角膜上皮的临床检查及聚合酶链反应分析。
结果
一名10岁健康儿童在全身性水痘康复后出现伴有假树枝状病变的慢性复发性水痘病毒角膜炎。对刮除的假树枝状病变进行分析，水痘带状疱疹病毒（VZV）DNA反复呈阳性，单纯疱疹病毒（HSV）DNA呈阴性。口服阿昔洛韦和局部使用糖皮质激素滴眼液治疗可有效消除假树枝状病变；然而，停药后疾病复发。
结论
儿童水痘病毒上皮性角膜炎可能是一种需要长期治疗的复发性慢性疾病。
Zotero 插件