Zhao Baolu
Center for Brain and Cognitive Sciences, Institute of Biophysics, Academia Sinica, Beijing, People's Republic of China.
Mol Neurobiol. 2005;31(1-3):283-93. doi: 10.1385/MN:31:1-3:283.
The author reviews the studies on the preventing effects of natural antioxidants, such as vitamins E and C, flavonoids, and polyphenols on neurodegenerative diseases, especially summarizing the results on the protective effect of ginkgo biloba extract on neuron cells, preventing effects of green tea polyphenols on apoptosis of PC12 cells (Parkison's disease model), preventing effects of genestien on amyloid-beta-induced apoptosis of hippocampal neuronal cells (Alzhemer's disease model), and preventing effect of Crataegus flavonoids on ischemic-reperfusion damage to the brain of the Mongolian gerbil (stroke model) in the laboratory.
作者综述了天然抗氧化剂,如维生素E、维生素C、类黄酮和多酚对神经退行性疾病的预防作用的研究,特别总结了银杏叶提取物对神经元细胞的保护作用、绿茶多酚对PC12细胞(帕金森病模型)凋亡的预防作用、染料木黄酮对淀粉样β蛋白诱导的海马神经元细胞(阿尔茨海默病模型)凋亡的预防作用,以及山楂黄酮对蒙古沙鼠脑缺血再灌注损伤(中风模型)的预防作用的实验室研究结果。