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识别植物源性天然药物对抗氧化应激和神经退行性疾病。

Identifying Plant-Based Natural Medicine against Oxidative Stress and Neurodegenerative Disorders.

机构信息

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028 Johannesburg, South Africa.

出版信息

Oxid Med Cell Longev. 2020 Sep 15;2020:8648742. doi: 10.1155/2020/8648742. eCollection 2020.

Abstract

Free radicals and oxidative stress are among the most studied factors leading to the imbalance in mental health. With no exception, free radicals also damage neuronal cells, leading to various degenerative diseases. With existing modern medications, around 80% of the world population relies on herbal medicine for various ailments. Phytochemicals in plants have a wide range of pharmacological properties, the major being their ability to scavenge free radicals. Plant polyphenols are among the major class of antioxidants identified in plants. This antioxidative property of plant compounds and their ability to downgrade the process of oxidative stress can be used to treat neurodegenerative diseases. However, selecting plants and their active compounds is a crucial step in framing the mechanism of action underlying their therapeutic potential.

摘要

自由基和氧化应激是导致心理健康失衡的最受研究关注的因素之一。自由基也会破坏神经元细胞,导致各种退行性疾病,这也不例外。在现有的现代药物中,全球约有 80%的人口依赖草药治疗各种疾病。植物中的植物化学物质具有广泛的药理特性,主要是它们清除自由基的能力。植物多酚是植物中发现的主要抗氧化剂类别之一。植物化合物的这种抗氧化特性及其降低氧化应激过程的能力可用于治疗神经退行性疾病。然而,选择植物及其活性化合物是确定其治疗潜力的作用机制的关键步骤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c14f/7519196/3e45a9bbe763/OMCL2020-8648742.001.jpg

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