自身抗N导致的严重溶血性贫血

Severe hemolytic anemia due to auto anti-N.

作者信息

Immel C C, McPherson M, Hay S N, Braddy L R, Brecher M E

机构信息

Transfusion Medicine Service, UNC Hospitals, 1021 East Wing, 101 Manning Drive, Chapel Hill, NC 27514, USA.

出版信息

Immunohematology. 2005;21(2):63-5.

PMID:15954806

Abstract

Auto anti-N is infrequently encountered and, in most reported cases, does not cause clinical hemolysis. This case reports an auto anti-N associated with severe hemolytic anemia (Hb=2.7 g/dL) in a 6-year-old Caucasian girl with a history of vomiting, fever, and abdominal pain. Upon admission, she was found to have a metabolic acidosis, secondary to her severe anemia, with abnormal liver function tests. As in three other case reports, the autoimmune hemolytic anemia resolved, with disappearance of the auto anti-N, after corticosteroid therapy.

摘要

自身抗 -N 抗体很少见，在大多数报道的病例中，不会引起临床溶血。本病例报告了一名 6 岁白种女孩，有呕吐、发热和腹痛病史，其自身抗 -N 抗体与严重溶血性贫血（血红蛋白 =2.7 g/dL）相关。入院时，发现她因严重贫血继发代谢性酸中毒，肝功能检查异常。与其他三例病例报告一样，皮质类固醇治疗后，自身免疫性溶血性贫血得以缓解，自身抗 -N 抗体消失。