趋化因子对发热性尿路感染的反应。
Chemokine response to febrile urinary tract infection.
作者信息
Otto Gisela, Burdick Marie, Strieter Robert, Godaly Gabriela
机构信息
Division of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Lund University, Lund, Sweden.
出版信息
Kidney Int. 2005 Jul;68(1):62-70. doi: 10.1111/j.1523-1755.2005.00381.x.
BACKGROUND
Mucosal CXC chemokines recruit inflammatory cells to the infected urinary tract. The chemokine response repertoire of the urinary tract and the relationship to disease severity have not been examined, however.
METHODS
This study quantified CXC (CXCL1, CXCL3, CXCL5, CXCL8, CXCL9, and CXCL10) and CC (CCL2, CCL4, and CCL5) chemokines in sequential urine samples obtained from 50 patients with febrile urinary tract infections during 24 hours after diagnosis.
RESULTS
All patients had elevated chemokine levels, but bacteremic infections caused higher CXCL1, CXCL3, CXCL5, CXCL8, and CCL2 responses. CCL2 and CXCL8 levels were higher in patients with acute pyelonephritis symptoms and CCL2, CXCL3, CCL4, CXCL5, and CXCL10 were significantly correlated to C-reactive protein (CRP) and temperature. Women and men showed different chemokine responses.
CONCLUSION
Febrile urinary tract infections are accompanied by a complex chemokine response. The response magnitude reflects disease severity, and the repertoire is influenced by gender and underlying disease.
背景
黏膜CXC趋化因子可将炎性细胞募集至受感染的尿路。然而，尚未对尿路的趋化因子反应谱及其与疾病严重程度的关系进行研究。
方法
本研究对50例发热性尿路感染患者在诊断后24小时内采集的连续尿液样本中的CXC（CXCL1、CXCL3、CXCL5、CXCL8、CXCL9和CXCL10）和CC（CCL2、CCL4和CCL5）趋化因子进行了定量分析。
结果
所有患者的趋化因子水平均升高，但菌血症感染引起的CXCL1、CXCL3、CXCL5、CXCL8和CCL2反应更高。急性肾盂肾炎症状患者的CCL2和CXCL8水平更高，且CCL2、CXCL3、CCL4、CXCL5和CXCL10与C反应蛋白（CRP）和体温显著相关。女性和男性表现出不同的趋化因子反应。
结论
发热性尿路感染伴有复杂的趋化因子反应。反应强度反映疾病严重程度，反应谱受性别和基础疾病影响。
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