McKenna J P, Cox J L
Medical Center, Beaver, Pa., Inc.
Am Fam Physician. 1992 Jun;45(6):2595-602.
Transdermal nicotine systems are a useful adjunct to smoking cessation. The larger-sized nicotine patches provide steady-state replacement of approximately 50 percent of the average serum nicotine level obtained by smoking one to one and one-half packs of cigarettes a day. This level is sufficient to prevent many symptoms of nicotine withdrawal, including physical craving, irritability, anxiety, restlessness, hostility, hunger and difficulty concentrating. In double-blind, placebo-controlled trials, transdermal nicotine systems have been about twice as successful as placebo in helping patients stop smoking.
经皮尼古丁系统是戒烟的一种有用辅助手段。较大尺寸的尼古丁贴片能提供相当于每天吸食1至1.5包香烟所获平均血清尼古丁水平约50%的稳态替代量。这一水平足以预防许多尼古丁戒断症状，包括身体上的渴望、易怒、焦虑、烦躁不安、敌意、饥饿和注意力难以集中等。在双盲、安慰剂对照试验中，经皮尼古丁系统在帮助患者戒烟方面的成功率约为安慰剂的两倍。
