Sloan R W
Department of Family Medicine, York Hospital, Pennsylvania.
Am Fam Physician. 1992 Jun;45(6):2709-18.
The elderly comprise 12 percent of the U.S. population but consume 33 percent of all prescription drugs. The incidence of adverse drug reactions is significantly higher in persons over age 65 than in younger population groups. The increased risk of adverse drug effects is related to decreased organ reserve capacity, to altered pharmacokinetics and pharmacodynamics, and to polypharmacy with associated drug-drug and drug-disease interactions. An organized therapeutic plan and critical evaluation of the list of drugs an elderly patient is taking will help in establishing a safe and effective drug regimen.
老年人占美国人口的12%，却消耗了所有处方药的33%。65岁以上人群药物不良反应的发生率明显高于年轻人群体。药物不良反应风险增加与器官储备能力下降、药代动力学和药效学改变以及多种药物联用导致的药物相互作用和药物与疾病相互作用有关。制定有组织的治疗计划并对老年患者正在服用的药物清单进行严格评估，将有助于建立安全有效的药物治疗方案。
