Marniemi Jukka, Alanen Erkki, Impivaara Olli, Seppänen Ritva, Hakala Paula, Rajala Tapio, Rönnemaa Tapani
National Public Health Institute, Department of Health and Functional Capacity, Peltolantie 3, FIN-20720 Turku, Finland.
Nutr Metab Cardiovasc Dis. 2005 Jun;15(3):188-97. doi: 10.1016/j.numecd.2005.01.001.
According to a widespread hypothesis, antioxidative vitamins and trace elements may protect the body against atherosclerotic diseases, especially in the elderly. We assessed dietary and serum vitamins and minerals for prediction of acute myocardial infarction (AMI) and stroke in elderly subjects.
In a population-based health survey with special emphasis on the diet, subjects aged 65-99 years were followed up for up to 10 years. The study population consisted of 361 men and 394 women. Information on individual food consumption was elicited by means of dietary history interviews. Serum vitamins and mineral elements were analysed utilizing commonly applied biochemical methods. Prediction analyses were based on 130 cases accumulated in the AMI group, 70 subjects in the stroke group, and corresponding control subjects. The cases were determined on the basis of revised information from the National Register of Cases of Death, and from the National Hospital Discharge Register. Low intake of vitamin D (p = 0.011) and low serum levels of 1,25-dihydroxy-vitamin D (p = 0.0053) were significantly predictive of stroke when adjusted for age, gender, smoking and functional capacity. On the other hand, high dietary intakes of two flavonoids, luteolin (p = 0.0096) and kaempferol (p = 0.002) were associated with lowered risk of AMI. Furthermore, low serum levels of iron predicted both AMI (p = 0.013) and stroke (p = 0.019). The results remained essentially unchanged when adjusted for additional major risk factors of atherosclerosis.
From the items in the dietary interview, low intakes of vitamin D and certain flavonoids emerged as the sole predictors of AMI and stroke. In biochemical analyses, on the other hand, these disorders were predicted only by low levels of 1,25-dihydroxy-vitamin D and iron in the serum.
根据一种广泛流传的假说，抗氧化维生素和微量元素可能保护机体预防动脉粥样硬化疾病，尤其在老年人中。我们评估了饮食及血清中的维生素和矿物质，以预测老年受试者急性心肌梗死（AMI）和中风的发生。
在一项特别关注饮食的基于人群的健康调查中，对65 - 99岁的受试者进行了长达10年的随访。研究人群包括361名男性和394名女性。通过饮食史访谈获取个体食物摄入信息。利用常用生化方法分析血清维生素和矿物质元素。预测分析基于AMI组积累的130例病例、中风组的70名受试者以及相应的对照受试者。病例根据来自国家死亡病例登记册和国家医院出院登记册的修订信息确定。在校正年龄、性别、吸烟和功能能力后，维生素D摄入量低（p = 0.011）和血清1,25 - 二羟维生素D水平低（p = 0.0053）是中风的显著预测因素。另一方面，两种黄酮类化合物木犀草素（p = 0.0096）和山奈酚（p = 0.002）的高饮食摄入量与降低AMI风险相关。此外，血清铁水平低预测AMI（p = 0.013）和中风（p = 0.019）。在校正动脉粥样硬化的其他主要危险因素后，结果基本保持不变。
从饮食访谈项目来看，维生素D和某些黄酮类化合物的低摄入量是AMI和中风的唯一预测因素。另一方面，在生化分析中，这些疾病仅由血清中1,25 - 二羟维生素D和铁的低水平预测。
