Hamerman D
Department of Medicine and Resnick Gerontology Center, Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA.
QJM. 2005 Jul;98(7):467-84. doi: 10.1093/qjmed/hci077. Epub 2005 Jun 13.
Osteoporosis and atherosclerosis are both widely prevalent in an ageing population, and induce serious morbidities and death. There is growing evidence that in addition to their relationship to ageing, osteoporosis and atherosclerosis are also linked by biological associations. This article reviews their clinical interrelations, discusses the basic biology of bone and the arterial wall, and presents five examples that illustrate their biological linkages. Current therapeutic approaches emerging from these linkages, including statins, bisphosphonates, and the thiazolidinediones, have dual effects on bone and the vasculature. Additional therapies derived from experimental studies that enhance bone density and reduce atherogenesis hold further promise to diminish the morbidity and mortality of osteoporosis and atherosclerosis, with attendant benefits to society.
骨质疏松症和动脉粥样硬化在老年人群中都广泛存在，并会引发严重疾病和死亡。越来越多的证据表明，除了与衰老有关外，骨质疏松症和动脉粥样硬化还通过生物学关联相互联系。本文综述了它们的临床相互关系，讨论了骨骼和动脉壁的基础生物学，并给出了五个例子来说明它们的生物学联系。从这些联系中涌现出的当前治疗方法，包括他汀类药物、双膦酸盐和噻唑烷二酮类药物，对骨骼和血管系统都有双重作用。来自实验研究的其他疗法，既能提高骨密度又能减少动脉粥样硬化的发生，有望进一步降低骨质疏松症和动脉粥样硬化的发病率和死亡率，给社会带来相应益处。
