Omura Yasushi, Nishio Yoshihiko, Kashiwagi Atsunori
Shiga University of Medical Science, Department of Medicine, Division of Endocrinology and Metabolism.
Clin Calcium. 2007 Mar;17(3):346-53.
Many epidemiological studies have shown an association between osteoporosis and vascular calcification or atherosclerotic diseases (coronary heart disease, stroke, peripheral vascular disease) in the elderly or postmenopausal women. These results indicate that osteoporosis and atherosclerosis might be linked by common risk factors or pathological mechanisms. Dyslipidemia has the correlation to both osteoporosis and atherosclerosis. Statins, nitorogen-containing bisphosphonates, and estrogens have the favorable effects on lipid profiles as well as vasculature, or bone mineral density. Thus, these therapeutic approaches might have dual effects on bone and vasculature.
许多流行病学研究表明，在老年人或绝经后女性中，骨质疏松症与血管钙化或动脉粥样硬化疾病（冠心病、中风、外周血管疾病）之间存在关联。这些结果表明，骨质疏松症和动脉粥样硬化可能通过共同的风险因素或病理机制相联系。血脂异常与骨质疏松症和动脉粥样硬化均相关。他汀类药物、含氮双膦酸盐和雌激素对血脂水平以及血管系统或骨密度具有有益作用。因此，这些治疗方法可能对骨骼和血管系统具有双重作用。
