解压与加载：DNA解旋酶和RFC钳位装载复合体在姐妹染色单体黏附中的作用
Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion.
作者信息
Skibbens Robert V
机构信息
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA.
出版信息
J Cell Biol. 2005 Jun 20;169(6):841-6. doi: 10.1083/jcb.200503129. Epub 2005 Jun 13.
Abstract
It is well known that the products of chromosome replication are paired to ensure that the sisters segregate away from each other during mitosis. A key issue is how cells pair sister chromatids but preclude the catastrophic pairing of nonsister chromatids. The identification of both replication factor C and DNA helicases as critical for sister chromatid pairing has brought new insights into this fundamental process.
摘要
众所周知，染色体复制的产物会配对，以确保姐妹染色单体在有丝分裂期间彼此分离。一个关键问题是细胞如何使姐妹染色单体配对，同时防止非姐妹染色单体发生灾难性配对。复制因子C和DNA解旋酶被鉴定为对姐妹染色单体配对至关重要，这为这一基本过程带来了新的见解。
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