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解压与加载：DNA解旋酶和RFC钳位装载复合体在姐妹染色单体黏附中的作用

Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion.

作者信息

Skibbens Robert V

机构信息

Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA.

出版信息

J Cell Biol. 2005 Jun 20;169(6):841-6. doi: 10.1083/jcb.200503129. Epub 2005 Jun 13.

DOI:10.1083/jcb.200503129
PMID:15955849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2171654/
Abstract

It is well known that the products of chromosome replication are paired to ensure that the sisters segregate away from each other during mitosis. A key issue is how cells pair sister chromatids but preclude the catastrophic pairing of nonsister chromatids. The identification of both replication factor C and DNA helicases as critical for sister chromatid pairing has brought new insights into this fundamental process.

摘要

众所周知，染色体复制的产物会配对，以确保姐妹染色单体在有丝分裂期间彼此分离。一个关键问题是细胞如何使姐妹染色单体配对，同时防止非姐妹染色单体发生灾难性配对。复制因子C和DNA解旋酶被鉴定为对姐妹染色单体配对至关重要，这为这一基本过程带来了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8500/2171654/cdc3b125be7c/200503129f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8500/2171654/6c49601886d4/200503129f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8500/2171654/eb15b4d92b47/200503129f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8500/2171654/cdc3b125be7c/200503129f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8500/2171654/6c49601886d4/200503129f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8500/2171654/eb15b4d92b47/200503129f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8500/2171654/cdc3b125be7c/200503129f3.jpg

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本文引用的文献

1
Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis.酵母中一种导致有丝分裂期间非随机染色体丢失的突变的特征分析。
Genetics. 1978 Apr;88(4 Pt 1):651-71.
2
Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion.罗伯茨综合征由ESCO2基因突变引起，ESCO2是酵母ECO1的人类同源物，对姐妹染色单体黏连的建立至关重要。
Nat Genet. 2005 May;37(5):468-70. doi: 10.1038/ng1548. Epub 2005 Apr 10.
3
Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
上调 DNA 复制和姐妹染色单体粘连蛋白 1 表达对肝癌增殖和预后的影响。
Chin Med J (Engl). 2018 Dec 5;131(23):2827-2835. doi: 10.4103/0366-6999.246076.
4
The Main Role of Srs2 in DNA Repair Depends on Its Helicase Activity, Rather than on Its Interactions with PCNA or Rad51.Srs2 在 DNA 修复中的主要作用取决于其解旋酶活性，而不是其与 PCNA 或 Rad51 的相互作用。
mBio. 2018 Jul 17;9(4):e01192-18. doi: 10.1128/mBio.01192-18.
5
Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.没有凝聚作用的黏合蛋白：酿酒酵母中 Pds5 的一个新角色。
PLoS One. 2014 Jun 25;9(6):e100470. doi: 10.1371/journal.pone.0100470. eCollection 2014.
6
Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus.核仁蛋白在 HIV-1 Tat 响应下的运输：重排核仁。
PLoS One. 2012;7(11):e48702. doi: 10.1371/journal.pone.0048702. Epub 2012 Nov 15.
7
Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts.在正常人类成纤维细胞中，Timeless 独立于 Tim-Tipin 复合物发挥作用，促进姐妹染色单体黏合。
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8
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9
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4
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