Högl B, Kiechl S, Willeit J, Saletu M, Frauscher B, Seppi K, Müller J, Rungger G, Gasperi A, Wenning G, Poewe W
Department of Neurology, Innsbruck Medical University, Anichstr. 35, 6020 Innsbruck, Austria.
Neurology. 2005 Jun 14;64(11):1920-4. doi: 10.1212/01.WNL.0000163996.64461.A3.
To assess the prevalence and severity of restless legs syndrome (RLS) in the general community and to investigate its potential relationship with iron metabolism and other potential risk factors.
This was a cross-sectional study of a sex- and age-stratified random sample of the general population (50 to 89 years; n = 701). The diagnosis of RLS was established by face-to-face interviews; severity was graded on the RLS severity scale. Each subject underwent a thorough clinical examination and extensive laboratory testing.
The prevalence of RLS was 10.6% (14.2% in women, 6.6% in men); 33.8% of all patients with RLS had mild, 44.6% had moderate, and 21.6% had severe disease expression. None had been previously diagnosed or was on dopaminergic therapy. Free serum iron, transferrin, and ferritin concentrations were similar in subjects with and without RLS. However, soluble transferrin receptor (sTR) concentrations were different in subjects with and without RLS (1.48 vs 1.34 mg/L; p < 0.001). Female sex and high sTR independently predicted the risk of RLS.
This large survey confirms the high prevalence, female preponderance, and underrecognition of restless legs syndrome in the general community. Although two-thirds of patients had moderate to severe disease, none was on current dopaminergic therapy.
评估普通人群中不宁腿综合征（RLS）的患病率和严重程度，并调查其与铁代谢及其他潜在风险因素之间的潜在关系。
这是一项对普通人群（50至89岁；n = 701）进行的按性别和年龄分层的随机抽样横断面研究。通过面对面访谈确诊RLS；根据RLS严重程度量表对严重程度进行分级。每位受试者均接受了全面的临床检查和广泛的实验室检测。
RLS的患病率为10.6%（女性为14.2%，男性为6.6%）；所有RLS患者中，33.8%为轻度，44.6%为中度，21.6%为重度。此前均未被诊断或接受多巴胺能治疗。有无RLS的受试者血清游离铁、转铁蛋白和铁蛋白浓度相似。然而，有无RLS的受试者可溶性转铁蛋白受体（sTR）浓度不同（1.48对1.34 mg/L；p < 0.001）。女性和高sTR独立预测RLS风险。
这项大规模调查证实了普通人群中不宁腿综合征的高患病率、女性优势及未被充分认识的情况。尽管三分之二的患者患有中度至重度疾病，但目前均未接受多巴胺能治疗。
