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一种用于治疗颈部肌张力障碍的不含复合蛋白的新型A型肉毒杆菌毒素。

A new botulinum toxin type A free of complexing proteins for treatment of cervical dystonia.

作者信息

Benecke R, Jost W H, Kanovsky P, Ruzicka E, Comes G, Grafe S

机构信息

Department of Neurology, University of Rostock, Gehlsheimer Strasse 20 D-18147, Rostock, Germany.

出版信息

Neurology. 2005 Jun 14;64(11):1949-51. doi: 10.1212/01.WNL.0000163767.99354.C3.

DOI:10.1212/01.WNL.0000163767.99354.C3
PMID:15955951
Abstract

A new botulinum toxin type A free of complexing proteins (NT 201) was compared with BOTOX in patients with cervical dystonia by means of a double-blind noninferiority trial. Four hundred sixty-three patients received IM injections of 70 to 300 U of NT 201 or BOTOX and were followed up over 16 weeks. The study clearly shows that NT 201 is at least as effective and safe as BOTOX.

摘要

通过一项双盲非劣效性试验，将一种不含复合蛋白的新型A型肉毒杆菌毒素（NT 201）与保妥适（BOTOX）在颈部肌张力障碍患者中进行了比较。463例患者接受了70至300 U的NT 201或保妥适的肌肉注射，并随访了16周。该研究清楚地表明，NT 201至少与保妥适一样有效和安全。

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