Miller K N, McClure S P
Department of Pathology, Akron City Hospital, Ohio.
Am J Clin Pathol. 1992 Jun;97(6):806-9. doi: 10.1093/ajcp/97.6.806.
An unusual case of uterine papillary adenofibroma involved by an invasive well-differentiated adenocarcinoma is reported. The diagnosis was established using a hysterectomy specimen from a 68-year-old woman who was initially examined for abdominal pain and vaginal bleeding. The tumor was a broad-based polypoid mass composed of papillary projections into clefts and cysts. These papillations were covered by a variety of epithelial types and focally involved by an infiltrating adenocarcinoma. The stroma was fibrous and collagenized with variable numbers of benign fibroblasts. The papillary adenofibroma is considered to be a benign mixed tumor of Müllerian origin. Fifteen other cases of uterine adenofibroma have been reported in the literature and only one of these was focally involved by an adenocarcinoma. The clinical and histologic features of this rare disease are reviewed.
报告了一例不寻常的子宫乳头状腺纤维瘤，伴有浸润性高分化腺癌。诊断基于一名68岁女性的子宫切除标本，该女性最初因腹痛和阴道出血接受检查。肿瘤为广基息肉样肿块，由向裂隙和囊肿内突出的乳头状结构组成。这些乳头被多种上皮类型覆盖，并局灶性被浸润性腺癌累及。间质为纤维性且胶原化，有数量不等的良性成纤维细胞。子宫乳头状腺纤维瘤被认为是起源于苗勒管的良性混合性肿瘤。文献中还报道了另外15例子宫腺纤维瘤，其中只有1例局灶性被腺癌累及。本文对这种罕见疾病的临床和组织学特征进行了综述。
