Strand Daniel, Rein Tobias
KTH Chemistry, Organic Chemistry, SE-100 44 Stockholm, Sweden.
Org Lett. 2005 Jun 23;7(13):2779-81. doi: 10.1021/ol050997g.
[structure: see text] A stereocontrolled convergent synthesis of the annonaceous acetogenin pyragonicin (1) is presented. The key intermediates were accessed using asymmetric Horner-Wadsworth-Emmons (HWE) methodology. A reagent controlled zinc-mediated stereoselective coupling, joining the two highly functionalized intermediates 3 and 4, then provided the core structure.
[结构：见正文] 报道了番荔枝乙酰精菌素吡拉戈菌素（1）的立体控制汇聚合成。关键中间体通过不对称霍纳-沃兹沃思-埃蒙斯（HWE）方法制备。一种试剂控制的锌介导立体选择性偶联反应，将两个高度官能化的中间体3和4连接起来，进而得到了核心结构。
