苯并(a)芘对小鼠卵巢及黄体体积的影响。

The effect of benzo(a)pyrene on murine ovarian and corpora lutea volumes.

作者信息

Miller M M, Plowchalk D R, Weitzman G A, London S N, Mattison D R

机构信息

Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock 72205.

出版信息

Am J Obstet Gynecol. 1992 May;166(5):1535-41. doi: 10.1016/0002-9378(92)91630-s.

DOI:10.1016/0002-9378(92)91630-s

PMID:1595809

Abstract

OBJECTIVE

Women who smoke have impaired fertility and experience menopause at an earlier age. This experiment determined the effect of benzo(a)pyrene, a polycyclic aromatic hydrocarbon contained in cigarette smoke, on murine ovarian volume, total corpora lutea volume, individual corpora lutea volumes, and corpora lutea numbers.

STUDY DESIGN

C57BL/6N mice were treated with intraperitoneal injections of 0 to 500 mg/kg benzo(a)pyrene in corn oil. The 20 mice at each dose were divided into four groups of five each and were killed at 1, 2, 3, or 4 weeks after treatment. Ovaries were serially sectioned and analyzed morphometrically.

RESULTS

Benzo(a)pyrene produced a dose- and time-dependent decrease in ovarian volume, total corpora lutea volume, and number of corpora lutea per ovary. This effect was transitory at low doses with complete recovery of corpora lutea by 4 weeks. Compensatory hypertrophy of the individual corpora lutea occurred during the recovery phase. Ovarian function did not return in animals treated with the two highest doses.