Rief Winfried, Barsky Arthur J
Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Psychoneuroendocrinology. 2005 Nov;30(10):996-1002. doi: 10.1016/j.psyneuen.2005.03.018.
Common physical symptoms such as abdominal pain, headache, back pain and dizziness play a major role for the health care system. Existing models for the development and maintenance of these symptoms emphasize a vicious circle with cognitive-perceptual, behavioral, and psychobiological components. In this manuscript, we present examples of psychobiological factors that might contribute to somatoform disorders. We emphasize that somatoform symptoms are not strictly mental events, but are associated with a diversity of biological processes. The possible role of the endocrine and immune system, amino acids and neurotransmitters, but also physiological activation and cerebral activity is exemplified. These approaches are categorized using a model of perception and filtering of bodily signals. Studies are needed that combine the investigation of different biological systems with assessments of psychological variables in longitudinal trials, but also experimental investigations in humans examining the interaction of behavior changes, biological variations, and body perception are still rare.
常见的身体症状，如腹痛、头痛、背痛和头晕，在医疗保健系统中起着重要作用。这些症状发生和持续存在的现有模型强调了一个包含认知-感知、行为和心理生物学成分的恶性循环。在本手稿中，我们列举了可能导致躯体形式障碍的心理生物学因素的例子。我们强调，躯体形式症状并非严格意义上的心理事件，而是与多种生物学过程相关。文中举例说明了内分泌和免疫系统、氨基酸和神经递质的可能作用，以及生理激活和大脑活动的作用。这些方法是根据身体信号的感知和过滤模型进行分类的。需要开展研究，在纵向试验中将不同生物系统的研究与心理变量的评估相结合，而且在人类中进行的检验行为变化、生物学变异和身体感知之间相互作用的实验研究仍然很少见。
