Reisner Yair, Gur Hilit, Reich-Zeliger Shlomit, Martelli Massimo F, Bachar-Lustig Esther
Weizmann Institute of Science, Department of Immunology, Rehovot, Israel.
Ann N Y Acad Sci. 2005 Jun;1044:70-83. doi: 10.1196/annals.1349.010.
Studies in mice and humans demonstrate that transplantation of hematopoietic progenitors in numbers larger than commonly used overcomes major genetic barriers. In vitro studies suggest that veto cells, within the population of hematopoietic progenitors, facilitate this favorable outcome. Tolerance induction can be further enhanced by other veto cells. Perhaps the most potent veto cell is the CD8(+) CTL. However, this cell is also associated with marked GVHD, which can be separated from the veto activity by generating anti-third party CTLs under IL-2 deprivation.
对小鼠和人类的研究表明，移植数量超过常用量的造血祖细胞可克服主要的遗传障碍。体外研究表明，造血祖细胞群体中的否决细胞促成了这一有利结果。其他否决细胞可进一步增强耐受性诱导。也许最有效的否决细胞是CD8(+)CTL。然而，这种细胞也与明显的移植物抗宿主病有关，通过在白细胞介素-2缺乏的情况下产生抗第三方CTL，可将其与否决活性分离。
