Cernilogar Filippo M, Orlando Valerio
Dulbecco Telethon Institute, Naples, Italy.
Biochem Cell Biol. 2005 Jun;83(3):322-31. doi: 10.1139/o05-040.
Polycomb group (PcG) and Trithorax group (TrxG) proteins work, respectively, to maintain repressed or active transcription states of developmentally regulated genes through cell division. Data accumulated in the recent years have increased our understanding of the mechanisms by which PcG and TrxG proteins regulate gene expression. The discovery that histone methylation can serve as a specific mark for PcG and TrxG complexes has provided new insight into the mechanistic function of this cell-memory system.
多梳蛋白家族（PcG）和三胸蛋白家族（TrxG）的蛋白质分别发挥作用，通过细胞分裂维持发育调控基因的抑制或活跃转录状态。近年来积累的数据增进了我们对PcG和TrxG蛋白质调控基因表达机制的理解。组蛋白甲基化可作为PcG和TrxG复合物的特异性标记这一发现，为这个细胞记忆系统的作用机制提供了新的见解。
