Hirsch N, Beckett A, Collinge J, Scaravilli F, Tabrizi S, Berry S
Department of Neuroanaesthesia, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
Anaesthesia. 2005 Jul;60(7):664-7. doi: 10.1111/j.1365-2044.2005.04221.x.
Variant Creutzfeldt-Jakob disease (vCJD) is associated with extensive prion infection of lymphoreticular tissues during the prolonged asymptomatic incubation period. Instruments exposed to infected tissues of preclinically infected individuals during medical or surgical procedures represent a potential risk of iatrogenic transmission of vCJD prions. We assessed the frequency of contamination with lymphoid tissue of single-use laryngoscope blades used for tracheal intubation for general anaesthesia. Using a cyto-centrifugation technique, lymphocytes were detected from 30% of laryngoscope blades studied. As prions resist routine sterilisation procedures, the use of non-disposable laryngoscope blades poses a risk of transmitting vCJD from patient to patient. The use of such instruments should be abandoned and disposable alternatives used.
变异型克雅氏病（vCJD）与在漫长的无症状潜伏期期间淋巴网状组织的广泛朊病毒感染有关。在医疗或外科手术过程中，接触临床前感染个体感染组织的器械存在医源性传播vCJD朊病毒的潜在风险。我们评估了用于全身麻醉气管插管的一次性喉镜叶片被淋巴组织污染的频率。使用细胞离心技术，在所研究的30%的喉镜叶片中检测到了淋巴细胞。由于朊病毒能抵抗常规消毒程序，使用非一次性喉镜叶片存在将vCJD从患者传播给患者的风险。应放弃使用此类器械，改用一次性替代品。
