Workman M L, Kaye V N, Anderson P M, Cunningham B L
Department of Plastic Surgery, University of Minnesota, Minneapolis.
Ann Plast Surg. 1992 Apr;28(4):381-5. doi: 10.1097/00000637-199204000-00016.
The association between melanoma and giant congenital nevocellular nevus has been well documented, although controversy still exists regarding the precise incidence. The following patient report illustrates the excision of malignant melanoma arising from a giant congenital nevocellular nevus in a 4-month-old infant. The child had malignant melanoma with deep dermal involvement diagnosed by incisional biopsy with positive margins. She underwent subsequent en bloc resection of the original biopsy site and nevus. The reexcision specimen showed no evidence of malignancy. No adjuvant chemotherapy was used. The child is disease free at 5 years. It is possible that very young children (infants) with melanoma arising in a giant congenital nevocellular nevus may have a good prognosis.
黑色素瘤与巨大先天性黑素细胞痣之间的关联已有充分记录，尽管关于确切发病率仍存在争议。以下病例报告展示了一名4个月大婴儿的巨大先天性黑素细胞痣发生恶性黑色素瘤的切除过程。该患儿经切开活检诊断为伴有真皮深层受累的恶性黑色素瘤，切缘阳性。随后她接受了原活检部位和痣的整块切除。再次切除标本未显示恶性证据。未使用辅助化疗。该患儿5岁时无疾病迹象。巨大先天性黑素细胞痣发生黑色素瘤的非常年幼（婴儿）患儿可能预后良好。
